BMS 582949

Name	BMS-582949
Synonyms	CS-2900 PS540446 BMS-582949 BMS 582949 BMS582949 BMS582949(HCl) 4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide Pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-
CAS	623152-17-0
EINECS	604-604-1

Molecular Formula	C22H26N6O2
Molar Mass	406.48
Storage Condition	-20℃
In vitro study	BMS-582949 inhibition of p38 activation in the cell, reducing the level of phosphorylation of p38. When p38 is activated by LPS, BMS-582949 treatment rapidly reverses this activation, whereby p38 phosphorylation is reduced. BMS-582949 is a double-acting inhibitor of p38, which inhibits both the activity of p38 kinase itself and the activation of p38 itself in cells. BMS-582949 binds to p38a, causing a conformational change in the p38a activation loop (which can be phosphorylated by an upstream kinase), thereby inhibiting its phosphorylation.
In vivo study	In mice, the clearance of BMS-582949 was 4.4/min/kg. After oral administration of 10 mg/kg BMS-582949, AUC0-8 h was 75.5 μm-h. The oral bioavailability BMS-582949 values were 90% in mice and 60% in rats.

Last Update：2024-01-02 23:10:35

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CAS: 623152-17-0
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Mobile: 18021002903
QQ: 3008007409

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BMS 582949

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